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I use Topamax for migraine prevention. It has cut down the number of migraines drastically and I don't get really bad migraines anymore.



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Evidence: The development of noninsulin-dependant diabetes in women with a history of gestational diabetes is not increased by use of COCs ( 440--447).

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The inhibition of carbonic anhydrase activity results in an overall decrease in excitatory neurotransmission and an increase of inhibitory neurotransmission.

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Low-dose topiramate as an adjunct to psychotherapeutic treatment is well tolerated and effective in reducing alcohol craving, as well as symptoms of depression and anxiety, present during the early phase of alcohol withdrawal.

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You should not use extended-release topiramate if you have metabolic acidosis and are also taking metformin.

The precise mechanisms by which topiramate exerts its anticonvulsant and migraine prophylaxis effects effects are unknown; however, preclinical studies have revealed four properties that may contribute to topiramate's efficacy for epilepsy and migraine prophylaxis.

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The actual adjustment should take into account 1) the duration of dialysis period, 2) the clearance rate of the dialysis system being used, and 3) the effective renal clearance of Topiramate in the patient being dialyzed.

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