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Response at three months is a good predictive factor for newly diagnosed chronic myeloid leukemia patients treated by recombinant interferon-alpha.
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Therefore, standard-risk patients with higher levels of end-induction MRD are not treated with the approaches described for standard-risk patients who have low end-induction MRD, but are usually treated with high-risk regimens.
The patient underwent continuous renal replacement therapy to try and correct his metabolic abnormalities, but despite the supportive management the patient died 5 days after the suspected time of ingestion.
Instead, quantitative real-time polymerase chain reaction (RT-PCR) using the international scale to monitor the BCR-ABL transcript levels is used.
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You make Plendil without food or a light meal, but take it the same way each time.
Myocardial biopsy revealed eosinophilic infiltration and degranulation, and the cardiogenic shock was reversed with the prompt institution of corticosteroid therapy.
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Primary pulmonary disease usually resolves without treatment.
The characteristic genetic abnormality of CML, the Philadelphia (Ph) chromosome, results from a reciprocal translocation between the long arms of chromosomes 9 and 22.
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Suspect limb- or life-threatening infections early and facilitate the diagnostic workup in diabetic patients.
Dual inhibition of the homologous recombinational repair and the nonhomologous end-joining repair pathways in chronic lymphocytic leukemia therapy.
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Secondary acute promyelocytic leukemia following chemotherapy for non-Hodgkin's lymphoma in a child.
Scientists are making great progress in understanding how changes in a person's DNA can cause normal bone marrow cells to develop into leukemia cells.
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Long-term outcome of initially homogenously treated and relapsed childhood acute lymphoblastic leukaemia in Austria--a population-based report of the Austrian Berlin-Frankfurt-Münster (BFM) Study Group.
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Nilotinib in the treatment of advanced gastrointestinal stromal tumours resistant to both imatinib and sunitinib.
Those who had low end-reinduction MRD were treated with chemotherapy only (no HSCT).
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This reduced binding capacity can be caused by either direct or indirect mechanisms, allowing a classification of Bcr-Abl mutations into two groups ().
In some types of cancer, the tyrosine kinase is abnormal, causing the uncontrolled growth of cancer cells.
Managing inadequate responses to frontline treatment of chronic myeloid leukemia: A case-based review.
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Imatinib mesylate should be taken with a large glass of water, after a meal.
Grade 1 periorbital swelling and lower extremity edema developed in 3 patients after the dose of imatinib mesylate was increased.
El perfil de toxicidad y las tasas de respuesta en niños son similares a los observados en los adultos.
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Total body irradiation correlates with chronic graft versus host disease and affects prognosis of patients with acute lymphoblastic leukemia receiving an HLA identical allogeneic bone marrow transplant.
Portopulmonary hypertension: imatinib as a novel treatment and the Emory experience with this condition”.
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Simvastatin: Imatinib may decrease the metabolism of Simvastatin.
As an example, HES is a systemic eosinophilic disease but it may also involve the gastrointestinal tract and not be associated with apparent causes as in primary gastrointestinal eosinophilia.
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Successful treatment of a chronic-phase T-315I-mutated chronic myelogenous leukemia patient with a combination of imatinib and interferon-alfa.
Review of use of imatinib in CML; hepatic toxicity occurs in 1-3%, but is rarely so severe to require drug discontinuation).
Dexamethasone (Systemic): May decrease the serum concentration of Imatinib.
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As the data base was too small to split the data set into a learning and a validation sample, no validation of results could be performed.
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Imatinib (IM), Nilotinib (NI), and Dasatinib (DA) or DMSO as vehicle control.
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Because only certain cancers will respond to imatinib, it is prescribed only for patients identified by specific diagnostic tests (for example, the Philadelphia chromosome abnormality test).
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Stated another way, the survival benefits achieved with bevacizumab can only be expected when used in accordance with the clinical evidence: continued until disease progression or treatment-limiting side effects.
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Submissions for line extensions, generics and all different submissions are reviewed internally or by the Medicine and Therapeutics Advisory Committee (DTAC). Generic drug products are thought of for inclusion on the formulary primarily based on provincial interchangeability lists and other related components.
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