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Is there a treatment for histoplasmosis? Severe infections or disseminated cases of histoplasmosis require treatment with antifungal medications. Itraconazole (Sporanox, Onmel), fluconazole (Diflucan), and amphotericin B (Ambisome, Amphotec; drug of choice for severe disease) are antifungal drugs that treat histoplasmosis.
How is histoplasmosis contracted? Histoplasmosis is most commonly transmitted when these spores become airborne, often during cleanup or demolition projects. Soil contaminated by bird or bat droppings also can transmit histoplasmosis, so farmers and landscapers are at a higher risk of contracting the disease.
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